How CBD Works With Your Nervous System

How CBD Works With Your Nervous System

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Cannabidiol (CBD) is a non-psychoactive compound extracted from particular hemp varieties cultivated for their low THC content. Unlike THC, CBD is not intoxicating, and offers unique benefits through separate mechanisms of action.

CBD affects the human nervous system by interacting with the endocannabinoid system. The key components of the endocannabinoid system are endocannabinoids, cannabinoid receptors, and enzymes. These components regulate and influence critical physiological processes to achieve homeostasis in mood, immunity, sleep, appetite, and pain signaling.

Unlocking The Science Of CBD

Endocannabinoids are the body's naturally occurring cannabinoids, interacting with the same cannabinoid receptors as phytocannabinoids. Imagine cannabinoids as “keys” that fit into “locks” that are cannabinoid receptors. CBD is believed to inhibit the enzymatic breakdown of excess endocannabinoids, increasing the presence of endocannabinoids and their cell-communicating effects. 

CB1 and CB2 are two known cannabinoid receptors. The CB1 receptors are primarily found in the central nervous system, the brain and spinal cord. They contribute to the psychoactive effects of cannabinoids and influence mood, appetite, and pain perception. The CB2 receptors are involved in the anti-inflammatory functions of the peripheral nervous system as well as the immunosuppressive function of cells.

CBD Relief Of Anxiety, Pain, And Disease Symptoms

The endocannabinoid system serves as a mediator of neuronal synaptic communication, maintaining homeostasis in the body and mind. CBD's interaction with endocannabinoid receptors is under investigation for its potential in autoimmune diseases, degenerative nerve diseases, and chronic conditions like heart disease, diabetes, rheumatoid arthritis, ulcerative colitis, and Alzheimer's disease. 

CBD may help regulate mood and alleviate anxiety by modulating serotonergic transmission. It potentially increases the presence of anandamide, a cannabinoid, by inhibiting its reuptake and enzymatic breakdown.

Ongoing clinical trials explore CBD's potential in managing substance withdrawal, headaches, and symptoms of conditions like pediatric epilepsy and cancer. For individuals in recovering post-surgery, CBD may modulate pain signaling to allow for a more comfortable and relaxed healing process. For patients of Parkinson's disease or multiple sclerosis, CBD may provide relief in response to neurological symptoms of chronic pain. 

CBD may impact the neurotransmission and neuromodulation of adenosine through mechanisms that inhibit its reuptake, ultimately leading to an increased presence of adenosine within the synapses between nerves. Adenosine plays a neuroprotective role in response to inflammation and cell degeneration. 

The Benefits of Full-Spectrum CBD

CBD is believed to inhibit the enzymatic breakdown of excess endocannabinoids, preserving their presence and thereby boosting their cell-communicating modulation of vital physiological processes. It may reduce certain effects of THC through negative allosteric modulation at CB1 receptors, while also enhancing other effects of THC at other receptors and activation sites. For example, CBD may mitigate the anxiety-inducing side effects of THC, while amplifying the relaxing sensations produced by THC.

Cannabinoids and terpenes may complement each other to maximize the relief CBD provides from pain, anxiety, insomnia, and inflammation. This Entourage Effect is captured in full-spectrum CBD tinctures and products, which contain phytocannabinoids, terpenes, flavonoids, and essential fatty acids, and are are verified by third-party, lab-testing to have THC levels of less than 0.3%. 

Bottle & Stone offers a variety of handcrafted products, infused with single-origin, certified Organic, and lab-tested CBD, empowering you to thrive naturally and achieve health and happiness on your own terms. 

Explore our CBD online to discover how #WeedBeGoodTogether or email us at

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